How to Improve Your Samples as a New Freelance Writer

Tests. The pass to getting your first independent composing work. Indeed, its that significant. Its not so much difficult to get a substance work with no example compositions. Despite the fact that I had an example when I handled my first gig, it was not pertinent by any stretch of the imagination. Better believe it, you read that right. I had one example to give when I pitched. Ouch! Be that as it may, guess what? I continued pitching and continued landing work. In the long run, I constructed my portfolio to what it is today. Over this time, I realized what makes a decent example. Its more than the genuine composition. Truth be told, the approaches to improve your examples can assist you with boosting the nature of your composition. Your Samples Your examples show a case of your composing capacity. Nothing talks more to possibilities than an example of your best composition. They can quickly tell whether you, Know about online substance Have connecting with and enrapturing composing Expertise to compose Are another essayist Its significant as another independent essayist to have in any event three example compositions added to your repertoire. They ought to likewise mirror the kind of keeping in touch with you need to get paid for. For instance, in the event that you are keen on public statement composing, having an example of an official statement is perfect. The equivalent goes for in the event that you need to compose blog entries or deals pages. All in all, how might you improve the examples you as of now have? 1. They Are Relevant Recollect when I referenced that I had the option to land my first gig utilizing an example that wasnt applicable? The pitch was for an auto-aficionado author and my example was for appropriate gut wellbeing. Go figure! Im amazed they recruited me ðÿ™‚ In the event that youre another essayist, I unequivocally propose you have tests that are pertinent to the pitch. In any case, Ive likewise referenced that its an extraordinary procedure †when youre new to pitch to everything without exception youre marginally intrigued by. Be that as it may, you cannot have 10 examples in 10 unique specialties. Rather, have up to three examples and to pick themes that are in your specialties. In the not too distant future you can pare down your specialties and compose for one specialty (as this can assist you with getting by as an author). For the time being, having around three can assist you with pitching to more employment advertisements. In the event that youre experiencing difficulty thinking of points that will wow your possibilities, probably the best thing you can do is take some time and examination writes in your specialty. For instance, lets state you are keen on writing in the WordPress specialty. Investigate these web journals to get a thought of themes you can make your examples around: Configuration Bombs Exquisite Themes Topic Isle From here discover themes that intrigue you. For instance, expounding on patterns for the following year shows prospects that you are up to speed in the WordPress business. You can likewise visit work promotions in your specialty and look at those online journals as an approach to see the sort of substance these organizations may need. At long last, on the off chance that you follow independent scholars in a similar specialty as you, you can likewise go to their portfolio and get a few plans to assist you with your examples. 2. They Are Formatted One of my annoyances as an author is composing that isnt organized for online perusers. I don't get this' meaning? Short Sentences Perusing on the web is sufficiently hard if youre on your versatile, so make it simple for everybody to have shorter sentences and shorter passages. By doing this, you make it simpler for individuals who filter your substance †that is 79% of us. Subheadings Do you perceive how this blog entry has subheadings? For what reason am I doing this? Its another method to help perusers really read my blog entry. We are for the most part scanners, so when we read a subheading we can choose if its value the read. One thing I dont like is when individuals utilize a rundown as a subheading. This is a no-no in my books. Your WordPress manager makes it simple to discover those features: Also, if youre composing your articles in Microsoft Word, you can discover you headings in your styles menu: CTA Most promoting content has a source of inspiration. This is something they need the peruser to do, for example, join to their bulletin, download an application or say something. On the off chance that youre keen on blog composing for instance, ensure your examples have a CTA toward the finish of your post. 3. They Are Published Ahh, heres the dubious part for some new independent authors. They dont have any distributed examples. Need to know something else about my first pitch that landed me the gig? My example was a PDF. Along these lines, better believe it, you can thoroughly land a gig with your PDFs, yet it will be more earnestly to land that gig. The individuals who are looking into your pitch and tests can locate a quality essayist with a distributed example and choose to employ them. What does being distributed have anything to do with handling a gig? It helps your validity as an independent essayist It shows that your composing is in excess of a diversion It shows youre genuine That is the reason I prescribe all new independent journalists to get their examples distributed. How might you make publishable examples? You can begin a blog and make blog entries in your specialty. For reasons unknown, I didnt do this. I made a blog and blogged about substance composing. I figure I did that since I was eager to simply blog! Another route is to visitor post. There are free and paid chances and it isn't so difficult to get your post distributed on another blog. Don't hesitate to send your pitch on the off chance that you need to visitor post over at FreelancerFAQs. For me, visitor posting is the most ideal approach to offer your examples to your possibilities. It unquestionably shows that you are an independent essayist. Be that as it may, if youre absolutely fresh out of the plastic new, the following best thing is to make an example record and distribute them either on Medium or LinkedIn Pulse. Medium is a blogging stage and some independent ventures really utilize Medium for their web journals. For instance, one of my customers utilizes Medium: Its simple to set up your profile and begin composing inside that hour. I set up a profile and coop my blog entries as an approach to develop my image and crowd. Thus, feel free to compose your examples on Medium! Or on the other hand, you can go to LinkedIn Pulse and make an example. I made a composing test in the computerized showcasing specialty (however I didnt realize that was my specialty at that point) from the get-go as another independent essayist: Both of these techniques work extraordinary for a shiny new independent author, so transform those PDFs into distributed connections on the web! Let Your Samples Speak For Themselves For a ton of new independent authors, getting your examples can be a test on the off chance that you havent made sense of your specialty or youre determined on getting a visitor post and not in any event, taking a gander at different approaches to get your examples. Be that as it may, on the off chance that you need to cause a to leave this, you have to organize your work. In my free course, I establish the framework on getting your first customer. What's more, the main thing you need is a specialty. From that point forward, its everything about getting tests and afterward from that point its opportunity to pitch. Things being what they are, do your examples represent themselves? I trust these three upgrades will assist you with landing more customers!

Design thinking- what is design thinking How might an organization Essay

Configuration thinking-what is configuration figuring How may an association make and continue upper hand through the strateg - Essay Example If there should arise an occurrence of assembling or creation, plan believing is a procedure of creating new thoughts with respect to an item or an assistance and afterward making required strides for the usage of those thoughts in the item improvement process. Configuration thinking identifies with the idea of advancement in that them two are pointed towards trying some new thoughts which can improve the matter of the organization. On the off chance that, in a market, an item is presented which was not accessible before in the market, that item is viewed as an inventive item with imaginative plan and usefulness that never existed. A portion of the primary highlights of configuration thinking in associations incorporate alteration of business procedures to make them versatile to the changed business condition, utilization of most recent innovation to make new items, and modernization of thoughts In this paper, we will examine the effect of configuration thinking on the key execution of organization. The paper will remember data for the advantages of configuration thinking for organizations, just as the manner in which configuration thinking and advancement can be utilized by an accommodation organization to accomplish upper hand in advertise. 2. ... McCallum (2010) states â€Å"creativity is significant, especially in business to stay serious, to give chances to staff and to make a satisfying domain which has no limitations on free thinking†. To accomplish upper hand, development and configuration believing are required in the item fabricating forms as well as in forms and hierarchical culture. Worrying on the requirement for advancement and configuration thinking, Hunt (2007) states â€Å"a organization can't exist and create without development advances in the cutting edge serious world†. Perception and consistent reasoning is the essential issue for configuration thinking. Configuration thinking likewise improves dynamic and critical thinking abilities, just as incorporates the utilization of Blue Ocean technique which is viewed as essential for acquiring improvement the business execution and accomplishing upper hand. Plan scholars make and consider a wide scope of alternatives to think of some specific choice in regards to process change. They fundamentally work to include some one of a kind and moving highlights to items with the goal that they become appealing for clients. Customers drive the organization towards upper hand. The more the clients of an organization will have, more will be the opportunity for the organization to accomplish serious edge in the market. Discussing the job of configuration thinking and advancement in accomplishing the objectives of upper hand for organizations, Berkun (2007, p.140) states â€Å"the development wins you cash, is pleasant to chip away at, or takes care of the difficult that premiums you†. As per Chesbrough (2003), no association can accomplish advertise mastery without bringing

How Debilitating Is Complex PTSD

How Debilitating Is Complex PTSD PTSD Print What Is Complex PTSD? By Matthew Tull, PhD twitter Matthew Tull, PhD is a professor of psychology at the University of Toledo, specializing in post-traumatic stress disorder. Learn about our editorial policy Matthew Tull, PhD Medically reviewed by Medically reviewed by Steven Gans, MD on June 05, 2017 Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Steven Gans, MD Updated on October 02, 2019 Post-Traumatic Stress Disorder Overview Symptoms & Diagnosis Causes & Risk Factors Treatment Living With In Children Jamie Grill / Getty Images First recognized as a condition that affects war veterans, post-traumatic stress disorder (PTSD) can be caused by any number of traumatic events, such as a car accident, natural disaster, near-death experience, or other isolated acts of violence or abuse.  When the underlying trauma is severe and repetitive, however, some mental health professionals make a distinction between PTSD and another form known as complex PTSD (C-PTSD). C-PTSD vs. PTSD While PTSD can develop in response to short-term exposure to a single traumatic event, C-PTSD only occurs when someone has experienced severe, repetitive trauma over a long period of time. The Diagnostic and Statistical Manual of Mental Disorders (DSM) has recognized PTSD as a diagnosis since its third edition, but C-PTSD is not yet mentioned as a separate disorder. Even so, many mental health professionals have started to distinguish between the two conditions. In 2018, the World Health Organization made the decision to include C-PTSD as its own separate diagnosis in the 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11).?? Symptoms According to the ICD-11, in addition to experiencing all of the core symptoms of PTSD, people with C-PTSD may also experience: Difficulty Controlling Emotions: You may experience an emotional flashback. This is when you have intense feelings that you originally felt during the trauma, such as fear, shame, or sadness. You may also experience severe depression, thoughts of suicide, or have difficulty controlling your anger.Detachment from Trauma (Dissociation): Dissociation is the minds way of coping with an intensely traumatic experience. Those who experience dissociation may feel detached from their surroundings, their actions, and their body. They may experience gaps in their memory surrounding the original trauma or an everyday task that reminds them of the trauma they experienced.Changes in Self-Perception Complex PTSD can cause a person to view themselves in a negative light. This negative self-image can include feeling as if they are different from other people and feelings of helplessness, guilt, or shame.Preoccupation With PerpetratorIt is not uncommon for people with C-PTSD to become fixated on their abuser. This can include becoming obsessed with the abuser, dissecting their relationship with the abuser, and becoming preoccupied with revenge.Difficulty with Personal RelationshipsSomeone with C-PTSD may develop unhealthy relationships because they find it difficult to interact with and trust others. Note that this is unique from borderline personality disorder (BPD) in that a person with C-PTSD often alienates themselves, as opposed to people with BPD who engage in unstable relationships that are often volatile.Changes in Beliefs People exposed to chronic or repeated traumatic events may lose faith in humanity and previously held beliefs. Causes The traumatic events connected to C-PTSD are long-lasting and generally involve some form of physical or emotional captivity. Some examples of ongoing trauma that can cause C-PTSD include: Childhood physical, emotional, or sexual abuseDomestic violenceHuman trafficking or forced prostitutionCaptivity Living in crisis conditions or war zones In these types of events, a victim is under the control of another person and does not have the ability to easily escape. Treatment Despite the complexity and severity of the disorder, C-PTSD can be treated with many of the same strategies as PTSD. But as experts continue to study C-PTSD, there is scientific research that supports a unique phase-based treatment approach.?? This treatment approach entails three phases: Reducing symptoms (i.e., through the use of medication) and improving self-management skillsReviewing and processing traumatic memoriesTransitioning out of therapy and engaging in community life C-PTSD can be a debilitating condition, but there are effective therapies available to address the chronicity and complexity of a persons past trauma.   If you or someone you care about has been exposed to repeated trauma and are struggling to cope, its important to seek help from a therapist who is familiar with PTSD. In addition to asking your primary care physician for a referral, there are many online resources that can help you find mental health providers in your area who treat PTSD.

John Steinbeck s Of Mice And Men - 1485 Words

The Connectivity of Death Death is inevitable. However, death arrives to people at different stages of their lives. Death is one thing that all people have in common; even books are connected because of the different deaths occurring in them. In S.E. Hinton’s The Outsiders, there are three major deaths occurring in the novel: Bob, Johnny, and Dally. Similarly, in John Steinbeck’s Of Mice and Men, there are also three major deaths: Candy’s dog, Curley’s wife, and Lennie. The Outsiders is a story depicting the life of Ponyboy Curtis, who is struggling to find his place in the world while battling the rival group, the Socs. Of Mice and Men is a story of two migrant workers, George and Lennie, who are bound together and share the dream of†¦show more content†¦Ã¢â‚¬Å"I had to. They were drowning you, Pony. They might have killed you. And they had a blade...they were gonna beat me up†¦Ã¢â‚¬  (pg. 57 Outsiders) Johnny and Ponyboy flee from town after Johnny commits murder, leading to Johnny’s. Johnny and Ponyboy hide in an abandoned church in Windrixville for 5 days, entertaining themselves by playing poker, reading, and smoking. When Dally finally arrives, Johnny declares that he is ready to turn himself in to the police. Naturally, this shocks Dally, but on their drive back to the abandoned church, they see that it’s on fire. Even worse, some children were trapped inside of the church, unable to escape. Immediately, Johnny and Ponyboy dash in, run through flames, and throw the kids out of the church. However, Ponyboy got caught on fire and Johnny had a piece of timber crash upon his back. This causes Johnny to be in critical condition in the hospital and be disabled for the rest of his life. Johnny dies from his wounds from the fire at the end of the novel. Similarly, Lennie’s death was also caused by his own actions. He is a mentally disabled character from Of Mice and Men, who holds onto his dream of owning and being able to tend his rabbits. When Curley’s wife begins to scream after Lennie pulls on her hair too tightly, Lennie begins to shake her, ultimately breaking her neck. Lennie didn’t mean any

Analyzing And Comprehend Works Of Literature And Math

It’s hard to believe that it’s already the end of the second quarter. Half of my junior year has passed by and the AP Language Composition exam is only a short one-hundred and eighteen days away. But in the past four months, I have been able to develop the skillsets needed to analyze and comprehend works of literature and conquer the AP exam. This second quarter has definitely brought growth in my ability to analyze and comprehend literature; however, I also experienced some stagnation in my writing abilities. Throughout the second quarter, I wrote several different essays in which I was able to develop and see my writing abilities. However, as the quarter progressed, I did not see a clear development in my writing abilities. Instead, my writing abilities fluctuated up and down like a roller coaster cart going up and down the hills. At the end of the first quarter, I had slowly improved my abilities in writing rhetorical analyses. In the last rhetorical essay of the qu arter (Last Child in the Woods by Richard Louv), I was able to recognize and express the rhetorical devices that I found in the article. My explanation for the author’s purpose for a rhetorical device was clear and well worded as shown in the following sentence. â€Å"When people hear this question, they will notice how they don’t watch nature anymore and then realize how they have grown apart from it.† However, there were still lapses in my diction and prose. At some points, my prose was not as elegant as itShow MoreRelatedEffectiveness Of Interactive Online Algebra Learning Tools1502 Words   |  7 Pagesthe observed differences were not significant enough to conclude a real difference between using interactive graphing tools and not using these tools. To be honest, the discussion of the data obtained from the study is difficult to follow and comprehend because of the terminology used such as â€Å"skewness and kurtosis values,† â€Å"negatively skewed and leptokurtic,† and â€Å"ANOVA using the Type III SS set.† Aside from the research that I did to understand the terminology, I also found that the graphs andRead MoreAnalysis Of Ray Bradburys Fahrenheit 4511113 Words   |  5 Pagesstruggle and hardship. Montag attempts to read books and see what they really mean, but he struggles to comprehend it to due to the lack of literature all his life. This is a perfect representation of how true learning needs the path of sufferance and acknowledgement to truly understand. This is similar to my own experience last year in my Algebra 1 class. It was a relatively a different class than math 8 and I was struggling due to the difficult content. However, after going through the struggle of stayingRead More Philosophy Ess ay1556 Words   |  7 Pagesperforming science experiments, students are more apt to excel when involved in learning experiences that allow them to put their interests and skills to work. Once a teacher realizes the interests and aptitudes of a student, she should encourage her to pursue them while continuing to stress the importance of basic subjects such as reading, writing, and math. I believe this scenario forms a solid foundation for a well-rounded person. The world we live in today is relative--knowledge is ever growingRead MoreA Teacher s Pedagogic Creed1608 Words   |  7 Pagesstudents; it seems like they play an active role in their students learning by finding a balance between developing a relationship with students but also not getting too involved with students lives. 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There are many reasons why Freire claims that problem-posing is the better of the two. The problem-posing technique, which is a liberating education, overall helps not only the students, but the teachers as well, because they work together. Since problem-posing is a liberating education, it acts as cognition, not just the idea of â€Å"depositing† the information into students (Freire, 1993). In the Pedagogy of the Oppressed, it stated that the teacher-student and the student-teacherRead MoreEffectiveness Of Interactive Online Algebra Learning Tools1693 Words   |  7 Pagesthe observed differences were not significant enough to conclude a real difference between using interactive graphing tools and not using these tools. To be honest, the discussion of the data obtained from the study is difficult to follow and comprehend because of terminology used such as â€Å"skewness and kurtosis values,† â€Å"negatively skewed and leptokurtic,† and â€Å"ANOVA using the Type III SS set.† Aside from the research that I did in order to understand the terminology, I did find that the graphsRead MoreComputer Science Is Not A Basic Complexity1808 Words   |  8 Pagesand math classes have increased in the past 20 years, the number of students enrolled in computer science has actually decreased. This can be attributed to the neglect exhibited by schools on computer science. In these 20 years, 1 billion computers have been built which makes computer science â€Å"integrated†: so baked into human life that it is not surprising to encounter, with social, technological, and futuristic aspects of the world. Unlike other integrated disciplines such as English or math, computerRead MoreAre Tee ns Magazines Be Considered As Academic Writings?1819 Words   |  8 Pagesperson view. Therefore, the strengths of the arguments are stated assertively, using language that is impersonal, not aggressive or indifferent. Diction refers to the choice of words an author uses and is heavily considered when writing a scholarly work. Awareness of the words used in the paper is vital in an academic writing because words that have almost the same denotation, a dictionary definition, can have unalike connotations, a slang definition. This is true in academic writing because wordsRead MoreMeta-Cognitive Process1794 Words   |  8 PagesCognitive strategies are the basic mental abilities we use to think, study, and learn (e.g., recalling information from memory, analyzing sounds and images, making associations between or comparing/ contrasting different pieces of information, and making inferences or interpreting text). They help an individual achieve a particular goal, such as comprehending text or solving a math problem, and they can be individually identified and measured. In contrast, metacognitive strategies are used to ensure that

Annotated Bibliography On Climate Change - 2488 Words

Annotated bibliography issue 1: Climate Change in Canada 1.Working together to fight Climate Change. (n.d.). Retrieved April 11, 2016, from http://climatechange.gc.ca/default.asp?lang=En Information from the Canadian Government website explains some factual information about what climate change is and how it is affecting Canada. From the website, it highlights some key information and basically explains what climate change is. It explains the causes and impacts of climate change and possible solutions to help the environment. On David Suzuki’s website, it explains in detail what climate change is and how it occurs through the burning of fossil fuels and cutting down trees. On his website, it has many great articles on different types of environmental issues. The website talks about what the impacts of climate change and how it would affect everyone all over the world through droughts and heavy rain and other types of extreme weather events. On the site, David states possible ways to help with the environment such as going carbon neutral or ways reduce on carbon emissions. Information includes detailed solutions for climate change and how to become a sustainable Earth. Article includes many different solutions such as foregoing the usage of burning fossil fuel, creating renewable sources of energy, preventing too much forestry, and building better infrastructures. All are great ways of improving the environment and making a better world to live in for the future.Show MoreRelatedClimate Change : Should We Be Worried? Essay777 Words   |  4 PagesClimate Change: Should We Be Worried? Global warming is one of the most stressed issues on mainstream media today, behind the war on terror. Although, should we be worried about it? 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The greenhouse effect refers to the warming resulting from certain gases such as carbon dioxide in Earth s atmosphere trapping heat. These gases traps heat but let light in, similarly to the glass walls of a greenhouse. The general belief is that mankind are chiefly responsible for global warming becauseRead MoreSummary : Water Scarcity And The Recognition Of The Human Right Safe Freshwater 1403 Words   |  6 Pages Professor Menton English 1 19 November 2015 Annotated Bibliography Type of Source: 13. Basic format for an article or other short work c. Database, 477 Curry, Elliot. â€Å"Water Scarcity and the Recognition of the Human Right to Safe Freshwater.† Journal of International Human Rights 9.1 (2010): 103-121. Academic Search Premier. Web. 19 Nov. 2015. Summary: Elliot Curry, a 2011 Juris Doctor candidate at the Northwestern University School of Law, notes that the western world is doing a great job atRead MoreThe Meat Industry And Dietary Recommendations873 Words   |  4 PagesAnnotated Bibliographies Ferdman A. Roberto. â€Å"The Meat Industry worst Nightmare could become reality.† The Washington Post. Washington Post. 7, Jan. 2015. Web. 20, Oct. 2015. http://www.washingtonpost.com/news/wonkblog/wp/2015/01/07/why-the-governments-new-dietary-guidelines-could-be-a-nightmare-for-the-meat-industry/ In The Washington Post, â€Å"The Meat Industry worst nightmare could become reality,† Roberto A. Ferdman, a reporter, acknowledges that meat production causes high amounts of carbonRead MoreAnnotated Bibliography On The Epidemiology, Aetiology And Pathophysiology Of Ross River Virus2259 Words   |  10 Pages Annotated Bibliography Prepared for Alannah Brown Course Coordinator Paramedic Clinical Foundations Prepared by Jessica Watson University of the Sunshine Coast Queensland, Australia September 2014 Word count: 2161 This annotated bibliography discusses the epidemiology, aetiology and pathophysiology of Ross River Virus. The research method that was undertaken was through the University of the Sunshine Coast library, using a range of databases and journals. The years in whichRead MoreAnnotated Bibliography On How Uniform Policy Swept U.s.919 Words   |  4 PagesAnnotated Bibliography Chandler, M. A. (2015, Oct 01). No uniform policy on what to wear. Washington Post Retrieved from http://sks.sirs.com.nauproxy01.national.edu In the Washington Post newspaper article stated the claim of how uniform policy swept U.S. in the school year of 2011-2012 to improve academics for the lacking students. Chandler says that according to federal data 20 percent of school districts made it necessary for students to wear uniforms. The uniform take-over caught the attention

Managing People and Organizations Negotiation or Mediation

Question: Describe about the Managing People and Organizations for Negotiation or Mediation. Answer: Introduction Conflicts will be solved through negotiation or mediation. Let's talk here of the conflict from the psychological perspective. Not all conflicts can or should be resolved through negotiation or mediation. For most of conflict negotiation it is usually a good settlement mechanism. Sometimes it is desirable not to let the negotiation and conflict comes to the end. Negotiation is a process whereby interested parties resolve disputes, agree on courses of action, seeking individual or collective benefits or seek to obtain results that serve their mutual interests. Conflicts can be faced with other types of mechanisms such as: The denial of the conflict (leading to a postponement of the conflict).The more spontaneous and natural tendency is domination (actually subjects too often what they seek is to dominate, subdue or overcome the contrary). Domination is often not fully aware (nor other attitudes adopted). This occurs both because society supports and premium competitiveness from psychology and must change this attitude (Armbrust, 2000). Conflict theory Conflict theory (TC) comes from the world of military strategy. The classical scholars of conflict, from Tucdedes and Sun Tzu, Machiavelli to Marx and Von Clausewitz, focused on a specific aspect of the conflict: power. These mechanisms are alternative ways to solve conflicts. Almost all things are negotiable. But there are others that are not. The negotiable: almost everything. The non-negotiable: central or held beliefs (abortion, belief in gods, is the core beliefs we identify ourselves. Rubin criticisms: there are indeed core beliefs but often the meaning has to depend on how they are addressed or express.It is absolute when the objectives are completely different when what wins it loses one another. Often it is modulated by social and cultural mechanisms (Biech, 2008). It is relative positions are perceived as antagonistic, but are not completely opposed (there are some compatible issues, which have in common). Most of the incompatibilities are relative. Desiderative thought: anchored to desire, emotional. It is not a rational thought. Perversion of the conflict: impression formation, the ultimate expression of the mystification of the formation of impressions is the self-fulfilling prophecy (the formation of impressions can create realities: a thought causes a behavior to the other which is interpreted as the first thought and returns the erroneous thinking the other in the form of behavior, confirming the first erroneous thinking. Or something like that!) (Conflicts, 2010). Cognitive reactance: the emotional reaction usually undirected cut to an individual when they perceive that their freedom is inadequate or unfairly limited. Goodness Dispute The primary connotation of the term conflict is negative. When this issue is raised there are 2 large positions: Sociological (Frankfurt School): The conflict is good, because it is the engine of social change. For Marxists conflict equal expression of change Constructive or negative attitude towards finding solutions in conflicts and negotiations No matter how the conflict works, it is important how people act. If people have a negative attitude, the conflict will be negative and if positive would be a constructive conflict. The consequences have the same problem as the cause. There is talk in terms of values and a problem to wait out, so it is difficult to intervene in a conflict. Any dispute involves a number of risks; to the extent possible be minimized. Risks and alter the channels of communication and interactions, increased perceptual distortions and prejudices, promoting polarity and hostility, self-concept and self-image, reduced sense of efficacy, decreased work motivation, in the absence cooperation; increased effort and loss of work capacity or when the conflict transcends loss of credibility of the organization and trust between users (Dahms, n.d.). Some authors speak of negative elements rather than risk conflict. Thomas-Kilmann Conflict Questionnaire This model has an advantage: a questionnaire to measure what the general attitude of the individual to the conflict is made. Measure this kind of attitude in 3 different situations: If the conflict has a superior to a subordinate or equal to it. The styles are often insufficient. These are general styles of conflict because there are so many styles of conflict and ways to address them. This point refers to the type of conflict; the next point is how to deal with conflict. Social skills related to conflict Intelligence was taken as a good predictor of the ability to solve problems. He also spoke of the existence of a factor G, because it could think there was a break between the intellectual capacity of an individual and the ability of social action. Over time the need to develop a new element had; social intelligence, emotional intelligence. Different forms of behavior can be employed skills to deal with different types of problems or conflicts. And these forms can be trained: train behavioral patterns to resolve conflicts. There is a possibility that individuals learn skills to address specific problems (identify the problem, standardize the performance, performance testing). Social skills play a key role role-playing and case analysis. Both techniques are the main approach to training.Also in the field of conflict and negotiation they have studied the social skills that best suit each case: Assertiveness It has to do with "self-affirmation". Feeling a person who claims his desires, his ideas the person manifests herself consistent. With regard to conflicts, assertive person is manifested in a resolute way, seeks to solve the problems, addressed to resolve the conflict and tends to the domination of the other party. No waiver of the interests of one, but neither attempts to pass above the other. Negotiation Way of resolving conflicts of all kinds. To negotiate must be conflict and the parties must know and analyze it. It is the most effective social skills. The processes of conflict and conflict negotiation intermingle, are not linear. (No strings like occur, first conflict and then negotiating) Unions now prefer negotiations to confrontation. The system is what we have, but what we need to do is improve it. Johari window Model It is a technique used for knowing the relationship between two or more interrelated parties within a social set up. A very important element in the negotiating power: balance / imbalance of power. In the case of imbalance, one party is more powerful than the other. This is not a negotiation as it occurs in all terms because the powerful party imposes rather than negotiate. But it does not have to, because with external pressures can be a good bargain (Davies, n.d.). For a negotiation to work well has to be a balance of power (not to be a very large imbalance). Power, often viewed from a quantitative perspective (who has more) but can also be qualitative (ability to generate a good negotiation, to influence third parties, coalitions do ...). It is the bargaining power. The power can also be rebalanced institutionally (eg. In divorce law welcomes more women because it is believed more helpless because there is work ..., the law protects women and rebalance the power in this conflict). Communication and interaction process: negotiation in this process. Thus, the negotiation falls squarely in social psychology, but also studied from the law, economics, and human resources. is an interdisciplinary event. The assumptions are that It is a peaceful process of dialogue and communication. It does not support pressures. Until they do not end the negotiation does not start. There is no negotiation under pressure. Types of negotiation intrapersonal Control: cognitive dissonance. In informal negotiation roles is given by the agents of conflict. Formally, the role of president, representatives, and consultants .There are indispensable roles (the negotiator) and there are other sides (third parties, consultants). Emotional and Social Competency Inventory (ESCI) This is a multi- rater diagnostic tool that is designed to vary and weigh the social intelligence and emotional competencies. It helps to build interrelation boundaries in conflicts and negotiations. Relationship "mixed motive": negotiator meets a role conflict. It is an antagonist of the other party; it must grant and obtain (2 reasons) things about him, to resolve the conflict: paradox negotiator. Negotiation is a voluntary process: one retires when he wants. This will give you great flexibility and the parties make a joint decision not imposed (Daft Marcic, 2014). It is not a perceptually anchored process: it is assumed that when the parties perceive that they will not give more others, but it is a perception and not know if you really would yield more other or not. A point that is often overlooked, both in business and in personal interactions, is to recognize if we are in a favorable situation for negotiation. In general, most of the situations faced by the interests of the people are resolvable through negotiation. However, on a few occasions, we find ourselves in situations that are not resolvable from the conceptual framework of a traditional negotiation (Phan Baurain, 2011). Strengths and weaknesses Conflict as an opportunity. A conflict can be an opportunity. Positive aspects of the conflict: engine of change, perceived effectiveness, new communication channels, opportunity to learn negotiation skills, opportunity to promote cohesion and group identity, opportunity to improve interpersonal perceptions, promoting recognition of different views, contribution the creation of positive values (cooperation, competition, respect, participation, etc.) Behind every conflict there is always a change. Ask whether it is good to conflicts to bring about change, presents the problem of riding a little conflict is real, and it probably is not the right approach. The first thing is to know which aspects you want to change and not all change involves conflict. In principle conflict does not invigorates if this does not change. Conflicts, when unchecked, have a tendency to increase (increasingly large and difficult to control). It is not just a quantitative increase conflict, but appears in other psychological and social phenomena that make it even more complex (Mayer, n.d.).If, however, a possible negotiation situation, our fears and distrusts make us adopt positions that we build ourselves the worst possible scenario. Therefore, mistaking a negotiating situation with conflict management is a serious mistake that we can not afford. Then we analyze the aspects that distinguish negotiation and conflict and give some guidelines to address these situations. Areas of Capabilities Distinguish between negotiation and conflict In general; the conflict word is used as a conflict of interests. In fact, it is considered to negotiation as one of the MARC's (alternative methods of dispute resolution).Let us now use the word conflict in a similar sense to that used in battles, i.e. situations where traditional negotiations would not lead to a good end result. Similarly, in business and, more commonly, in the political, ambushes occur, that is, actions that the other party does not seek an agreement, but to provoke a strong, devastating effect that put in a situation advantage and often permanently eliminate our chances (Tieleman Buelens, 2012). How to tell when we are in a negotiation situation or conflict? Normally, for a negotiation situation it is of, we need two conditions or rules: Rule gain of the parties states that negotiation is seen as a process in which all parties will win something. It is also called the rule we all win. We consider that which no one of these rules will lead to a conflict in that ambush, as we indicated before met. Conclusion The application of the theory of conflict (TC) to work or personal relationships is not without controversy. Assimilation or use of techniques that have been used by the great military strategists contains a certain aspect of violence and possibly perversion that has overshadowed this theory for many years. Only in recent years, with the award of several Nobel prizes applications conflict theory to biology or economics; they have restored the position that should have occupied this branch of knowledge. Like any other tool, CT is capable of being used for a few ethical purposes. We are going to focus on the ethical use and both useful, which is to encourage negotiations (Mayer, n.d.). When a negotiation takes place, there are many tensions affecting the negotiators. Arguments happen from one side to another and it is possible that at some point, communication degrading and reach a point of tension that makes the relationship, as we indicated in the rule of common sense, left broken and disable the way of trading. References Armbrust, W. (2000). Mass mediations. Berkeley: University of California Press. Biech, E. (2008). The Pfeiffer book of successful team-building tools. San Francisco, CA: Pfeiffer. Conflicts. (2010). Cambridge. Daft, R. Marcic, D. (2014). Building management skills. Mason, Ohio: South-Western Cengage Learning. Dahms, H. Mediations of social life in the 21st century. Davies, S. Johari's window. Dynes, R. (2008). Instant session plans for essential life skills. Lyme Regis, Dorset: Russell House Pub. Johari window. (2012). [Place of publication not identified]. Mayer, B. The conflict paradox. Nystuen, G. (2005). Achieving peace or protecting human rights?. Leiden: Martinus Nijhoff Publishers. Pfetsch, F. (2007). Negotiating political conflicts. New York: Palgrave Macmillan. Phan, L. Baurain, B. (2011). Voices, identities, negotiations, and conflicts. London: Emerald Group Pub. Phillips, B. (2001). The mediation field guide. San Francisco: Jossey-Bass. Tieleman, K. Buelens, M. (2012). Negotiations. Leuven: LannooCampus. Wall, J. (2008). Mediations in Cultural Spaces. Newcastle upon Tyne: Cambridge Scholars Pub.

Structural Features of Compare and Contrast Essay

Structural Features of Compare and Contrast Essay Persuasive essays are written to convince the target audience to share in a writer’s worldview. The writer can either decide to oppose or propose a topic. In each case, sound arguments have to be expressed to strengthen the topic. The writer has to deeply nurture understanding among readers. This is by stressing the reliability of the adopted standpoint and the unreliability of the countered standpoint. The thesis statement must also increase readers’ faith in the persuasive essay. A persuasive essay furnished with a strong thesis accomplishes the intended purpose. A strong thesis realizes the following: Gives readers a clear explanation of the essay’s key message. Ensures the essay retains rationality entirely. Below is a list of tips on writing a strong thesis for a persuasive essay. 1. Write a precise thesis A strong thesis informs readers of the purpose of the persuasive essay accurately. It adopts a thoughtful attitude in revealing arguments. The readers do not strain to understand what the writer is really talking about. A strong thesis example- online marketing has more power than traditional marketing methods because it overcomes geographical barriers in creating awareness about education opportunities in colleges. 2. Integrate an opinion A persuasive essay writing process requires expression of an authentic and sound opinion by a writer. Writers should write a thesis only if certain they have established a great opinion about the topic of concern. It is essential because a claim must be evident in the thesis. It should have the ability to be challenged by readers. Evaluating whether thesis statement has the potential to be challenged should be done. It is one way of finding out if strong thesis has been written. If it is discovered that the thesis is a mere presentation of facts that cannot be disputed, it is a sign of a weak thesis. 3. Include evidence Evidence is included to support a writer’s opinion in a thesis statement. Evidence adds weight to the thesis. It displays a writer’s wealth of information about the topic of discussion. When evidence is used, it is less difficult for a writer to persuade readers to accept his standpoint. The reader develop confidence in the topic which is sustained until the end. Sometimes a thesis can involve advancing an argument that readers are not conversant with. To maintain its credibility, evidence can be included and the claim made afterwards. Highlight the evidence first increases awareness among readers. They are able to establish to connect with the essay. 4. Address the why and how questions This is one technique of writing a strong thesis. It makes a thesis focused and practical. Failure to address either of these questions destabilizes the power of a thesis. The earlier example about online marketing and traditional marketing given in point number meets this requirement. It explains why online marketing is effective in contrast to the old-style marketing. The supremacy of a persuasive essay is not determined by how many arguments are advanced. It is the writing style that strengthens the arguments. One determinant that boosts the writing style is a well written thesis statement as explained in the aforementioned tips. Writers should continuously employ the tips to sway the mode of thinking of readers towards their perceptions.

How Jane Eyre and Shirley Valentine achieve independence Essay Example

How Jane Eyre and Shirley Valentine achieve independence Essay Example How Jane Eyre and Shirley Valentine achieve independence Paper How Jane Eyre and Shirley Valentine achieve independence Paper Essay Topic: Jane Eyre Literature Jane Eyre begins with Janes childhood and how she treated by the Reed family she lives with. She is bullied by Master John Reed and not treated with any respect or kindness by the older members of the household. Shirley Valentine has in a way a similar life but it starts much later in her lifetime: She is middle aged and married and feels not so much neglected but unappreciated by her husband and children (whom have grown up and left home). Then probably the most important part of each text is when the two characters take on a big change. For Jane it is when she is being bullied by Master Reed and is wrongly punished when she fights back which shows that she is not highly regarded in the household. She is punished by being locked in the red room and instead of just taking the punishment she fights and shouts at her captors. To further prove this was not normal behavior by Jane, Bessie (a housemaid) says she never did so beforecpt8 which miss Abbot replies But it was always in hercpt8. This last statement shows that this anger Jane suddenly let loose had been obvious to the staff in the house and was probably due to the behavior of Master Reed and other members towards her. This kind of behavior by Jane was showing an outside change in Charlottes world as the suffragettes were starting to make a change to society, as a few years before this kind of outburst by young women would never have been seen and definitely not tolerated. So I think this was a way for Charlotte Bronte to show that the world was changing and this was not a classic gothic novel of which we see evidence later in the text. So this was a new style of writing and was to change the way women were written about in books and even thought of in society. Shirley Valentine is looking back on her life when her biggest change in character appears. She looks back on her life when she and her husband Joe had just moved into their house, they were happy and Joe spent a lot of time at home with her and they were having fun. As the text turns back to the future it shows that Joes is working more and their lives have got into a rut and routine. Shirley thinks back again to a girl she met at school who was the opposite to Shirley at school; she tried at school and was well behaved while Shirley felt she just wasted her time at school. Its clear at the end of this section in the text she wishes she was in her school friends position now and thinks she would be living a more exciting and forfilling life. The exact time of Shirleys outbreak is when she brings home a steak for Joes dinner (which must be the same every week) and she feeds it to the dog next door, which Shirley feels is being neglected. When Joe comes home he gets angry with Shirley because she gave away his steak. Under all this Shirleys friend has offered her a trip to Greece which Shirley has not told Joe about. When Joe gets angry that evening she tells him and she shouts back at Joe, he almost convinces her its a stupid idea. Until she meets up with her school friend who is now a prostitute and tells Shirley to go, as does Shirleys neighbor who is very refined and quiet but seems to admire Shirley for leaving. The next day she left and had gone to Greece. Shirley left for Greece to escape from being a mother, as her daughter had just returned home from living away and was already treating Shirley like a slave, she also escaped Joe and the routine she had got into with him. In a way I think she was trying to be young again, which is unlike Jane, as Jane seems to want to grow up quickly. I dont think that Joe is entirely to blame for Shirleys change. It was written in the 1980s and this was a time when people were working harder and for longer hours than ever before. And the roles of couples at home were changing round and more women wanted to travel and see more of life as they had more time and money to do so. Going back to the Jane Eyre text Jane changed again when she met her friend Helen Burns at Lowood (an orphanage Jane is sent to by the Reed family). Which she is moved to, whom is thought to be the figure of Charlotte Brontes own older sister, Maria. Jane also becomes befriended with a young teacher at her school (Miss Evans). Together Helen and Miss Evans teach Jane to be a lot calmer and to change her pent up anger into passion, which would get Jane into less trouble. Miss Evans also shows a kindness Jane has never really had before and Jane sees that it is possible to have a friendship and mutual respect for people, like Jane has with Helen before Helen dies. Later on in Janes life she meets a man she has begun to work (Rochester) for and a relationship forms between them which I feel would not of happened if Jane had not had the guidance from her friends Helen and Miss Evans, as Rochester is very much as Jane was, and he too was in need of changing. This is similar for Shirley. While on holiday she meets a local man named Costas whom she has a relationship and she falls in love with the life she has now found and is not necessarily in love with Costas but just the thought that she is living. The end of this all comes when Shirley has to leave Greece as its the end of her holiday. Shirley decides to stay. Jane however end this part of her life and her relationship when she is to be married to Rochester who I think she has fallen in love with but still has doubts. When she is told that Rochester is already married, and his wife is mentally ill and she lives in the attic of his house. Instead of staying with Rochester Jane leaves and turns down a marriage of convenience to her cousin, St. John. Which is very similar to Shirley as Shirley decides not to go home and when she finds Costas in a bar with another woman and it is clear he is trying to woo her the same way he did to Shirley she is not bothered, she had turned down trying to be with Costas and Shirley phones her husband and asks him over to Greece to see her. I think that this experience has changed Joe, maybe he will appreciate Shirley more and they could have a better marriage. I think Shirley has now earned independence, instead of waiting on Joe and her children Joe now has to go to Shirley or risk loosing her. Shirley also has nobody she would rather be and is content with who she is and what she is doing. When Rochesters wife burns down his house and dies. Jane returns to him, now blind they then are together when she now leads him and she has independence and prowess over him. She had ignored any attempt of seduction from Rochester before his accident and she had refused a convenient marriage. She had also learned to forgive as when she went back to see the dying Mrs. Reed, when previously Jane had sworn never to return to her house and told Mrs. Reed: I will never call you an aunt again o long as I live. I will never come to see you when I am grown upcpt4 The fact that she did come back is the biggest sign of Janes change into an independent woman who is not ruled by her anger or overpowering family, lovers of friends. Jane was now independent. The texts have before seen as feminist text where both women are fighting against men in their lives and escaping control and traditional womens roles in society. For Shirley it was escape from a bored marriage and the home which she is practically a cleaner and cook. For Jane it was showing she was stronger in will than the men in her life and the text was not to be a traditional gothic novel in which, the heroine was usually saved by a man, unlike Jane who saved herself from abusive men (Such as Mr. Brockelhurst of her school who was a crushing force on the participants of the school) and Master Reed. Jane was also seen as romantic, but I dont think is. Jane is more independent than reliant on a partner whom she could easily of left and not married and I feel she might not be entirely happy or in love with Rochester due to the way they came together through tragedy and misfortune. To get across each story was done very differently. In Shirley Valentine, Shirley talks directly to the audience/reader but shown that she is talking to a wall which shows she is lonely and is a good way of reaching the audience and really getting a full show of thought and emotion. In Jane Eyre, Jane her life is observed and doesnt tell you her inner thoughts and views, but does give more room for speculation of how Jane feels about the people she encounters. I think that both characters value their independence most of all as they went so far to find. I also think they have similar views on the world around them and they both appreciate life more and can better now their lives have improved so much. A big difference in the style of these text is that it is a lot easier to relate to Shirley as she uses simple and modern language and its easier to follow her life and not get lost in complicated text. Although Shirley Valentine does go from present too past often and can be confusing to tell which is past or present. Though Janes life is chronological years are skipped forward between one chapter and another and so can again be confusing, especially when the text in Jane Eyre is decadent and almost unrealistic, and a lot of text maybe unnecessary. These differences tell us a lot about each character. Shirley is more down to earth and has a working class attitude and a strong accent which people can relate too. Jane sounds too had a wealthier upbringing and uses old language, which can set many readers out of touch with the character.

Managerial Marketing Term Paper Example | Topics and Well Written Essays - 2500 words

Managerial Marketing - Term Paper Example Retention of the customers is a system which must be mastered because it is the key to success and profitability. Businesses start with dreams of financial independence and financial security. No business can ever start to germinate and soar to success without a good idea, a business plan, sufficient capitalization and mastery of at least two aspects of business, human resource management and marketing management. This paper zeroes in on marketing management Target market is defined as the specific groups of customers that a business entity aims to capture (www.entrepreneur.com/encyclopedia/term/82498.html). Today, there is stiff competition in practically all kinds of business so it is imperative that to capture these target markets, there be target market strategies. It is also important that these target markets be identified, a process called market segmentation and a market niche be established (Daly,2001,p.50). To do this, an earnest research should be conducted to identify who these people are who have needs and wants that can be met by the services or the products of the business entity. If the business has already been started, then research begins with one's own existing customers. The questions to be answered are: who are these people; what sort of lives do they lead; who influence their buying decisions; what purchasing power do they have; what

Energy Sources Essay Example | Topics and Well Written Essays - 750 words

Energy Sources - Essay Example Surprisingly enough, the number of supporters of this source of energy was still high among the American participants of the McRumours forum that discussed the pros/cons of the nuclear energy use a few days after the Fukushima disaster.Apart from financial benefits, it is often said that nuclear power is environmentally friendly. For example, Steven Kerekesfrom the U.S. Nuclear Energy Institute believes that nuclear power generation plays a prominent role in the reduction of carbon emissions around the world. However, the arguments in favor of the nuclear energy use seem lame if one considers the arguments against it.The financial benefits are evidently outweighed by health risks associated with dealing with nuclear power waste and meltdown. While a generation of power seems relatively clean if compared to fossil fuels, the by-products need to be stored for hundreds of years in secluded facilities, some of which are situated â€Å"deep inside the mountains†. Given the fact tha t high-level radioactive waste has to be kept for hundreds of thousands of years till it is recognized safe to be released into the environment, opponents of nuclear waste rightfully contend that in reality there does not exist a place in the world which is truly safe. Indeed, as Jim Riccio, Nuclear Energy Campaign Director for Greenpeace, says â€Å"nothing you put the waste in will last longer than the waste itself, so burying it basically acquiesces to the fact that it will eventually leak†¦.just like every other radioactive dump site.†... participants of the McRumours forum that discussed the pros/cons of the nuclear energy use a few days after the Fukushima disaster (â€Å"McRumors Forum†, 2011, [online]).Apart from financial benefits, it is often said that nuclear power is environmentally friendly. For example, Steven Kerekesfrom the U.S. Nuclear Energy Institute believes that nuclear power generation plays a prominent role in reduction of carbon emissions around the world. It does not affect the climate, therefore it is quite clean and safe, Kerekes said in his interview to Earth Techling back in 2010 (DeFreitas, 2010, [online]). However, the arguments in favor of the nuclear energy use seem lame if one considers the arguments against it.The financial benefits are evidently outweighed by health risks associated with dealing with nuclear power waste and meltdown. While generation of power seems relatively clean if compared to fossil fuels, the byproducts need to be stored for hundreds of years in secluded fac ilities, some of which are situated â€Å"deep inside the mountains† (â€Å"Nuclear Power: Risks and Rewards†, 2012, [online]). Given the fact that high-level radioactive waste has to be kept for hundreds of thousands of years till it is recognized safe to be released into the environment, opponents of nuclear waste rightfully contend that in reality there does not exist a place in the world which is truly safe. Indeed, as Jim Riccio, Nuclear Energy Campaign Director for Greenpeace, says â€Å"nothing you put the waste in will last longer than the waste itself, so burying it basically acquiesces to the fact that it will eventually leak†¦.just like every other radioactive dump site.† (DeFreitas, 2010, [online]). Apart from this, the aftermaths of nuclear accidents that occasionally happen throughout

Synthesis of Aquasomes With Different Compositions

Synthesis of Aquasomes With Different Compositions Executive Summary of Research Proposal (maximum 300 words) (Please include the problem statement, objectives, research methodology, expected output/outcomes/implication, and significance of output from the research project) The last three decades have witnessed remarkable and breathtaking advances in the field of biotechnology, biochemistry, molecular biology and peptide synthesis. These developments have facilitated the pharmaceutical industry to make remarkable progress in the development of peptide and proteins as drugs. Since proteins are known to be involved in essentially all biological processes and reactions, they represent a promising class of therapeutics. Administration of these classes of drugs to humans is formidable challenge for biotechnologist as well as pharmacist. The biggest problems lying in their governance are physical and chemical instability, poor bioavailability and lack of knowledge for delivering them. These problems can be solved by using the aquasomes. Aquasomes combines biotechnology and nanotechnology approaches. These sugar balls are the recent addition in delivery systems that have wider applications in peptide and protein delivery. Aquasomes are three-layered self-assem bled nanostructures. They contain solid nanocrystalline core lile calcium phosphate coated with polyhydroxy oligomers over which peptide and protein are adsorbed. The carbohydrate coating protects the peptide from dehydration and stabilizes the active peptide molecules. Structural stability is provided by solid core. Aqausomes maintains the conformational integrity of peptide which makes it ideal carrier system for delivery of peptides. In the proposed work Aquasomes, a novel nano drug delivery system compassing of hydroxy apatite (HA) core having carbohydrate coating will be prepared. Urokinase will be immobilized on these nanostructures for thromobolytic therapy. The prepared systems will be characterized for size, shape, size distribution, enzyme loading efficiency, and in vivo performance. The in vivo performance of the formulated aquasome will be compared with standard urokinase preparation. In Aquasome the steric hindrance is provided by polyhydroxyoligomers between enzyme and blood component (Plasma protein). Later RES cells assist in removing exogenous material from blood stream .The polyhydroxy oligomers maintain three dimensional conformation of enzyme and also helps in deferring recognizition from RES cells. Therefore it is proposed that aquasome not only act as dehydroprotectant but also preserve the three dimensional conformation of enzyme in blood, which enhanced dramatically the half-life of enzyme. So it is expected that proposed system can add new dimension in delivery of urokinase through its rapid onset of action, maximal efficacy and safety Research background including Problem Statement, Hypothesis/Research Questions, Literature Reviews, Related References and Relevance to Goverment Policy, if any. Problem statement Urokinase is a serine protease enzyme which is widely used as an anti-thromboembolic drug in thrombolytic therapy. Urokinase is a strong plasminogen activator. Activation of plasmin activates a proteolysis cascade which breaks down the fibrin polymers of blood clots. This makes urokinase a very important drug against vascular diseases.Urokinase has a half-life of 10-20 mins in plasma. Due to which it is needed to given patient in a short time span for treatment.2 These problems can be solved by using the aquasomes. Aquasomes combines biotechnology and nanotechnology approaches. These sugar balls are the recent addition in delivery systems that have wider applications in peptide and protein delivery. Aquasomes are three-layered self-assembled nanostructures. They contain solid nanocrystalline core like calcium phosphate coated with polyhydroxy oligomers over which peptide and protein are adsorbed. The carbohydrate coating protects the peptide from dehydration and stabilizes the active peptide molecules. Structural stability is provided by solid core. Aqausomes maintains the conformational integrity of peptide which makes it ideal carrier system for delivery of peptides.3,4 Hypothesis Urokinase is a thrombolytic enzyme having half life of 10-20 minutes. In the present work is an attempt is to retain the spatial properties of streptokinase i.e. three-dimensional conformation, which is a freedom internal molecular rearrangement generated by intermolecular interaction and a freedom of bulk movement. Using aquasomes a high degree of molecular preservation may be achieved by virtue of the significant degree of retained biological activity. The aquasomes also avoid the elimination of drug by reticuloendothelial system therefore sustained delivery of drug may be achieved, and a circulating bioreactor could possibly be developed which may be used as preventive measure to avoid probable vascular embolism Research Questions Is it possible to immobilize Urokinase on aquasomes? Do Aquasmoes will be able to preserve the activity of Urokinase? Is it possible to achieve sustain release of urokinase with aquasomes after PEGylation? Is it possible to use similar platform for other peptide drugs? Literature review Current status of research and development in the subject Kossovsky et al.5( 1995) reported first synthesis of aquasomes for delivery of protein antigen and mussel adhesive protein. After that around fifteen research publications were appeared in scientific community utilizing aquasomes for peptide and drug delivery. Recently Aquasomes were used in delivery of peptide and drugs like insulin6 and indomethacin.7 Vyas et al.8 also used aquasomes for hepatitis antigen delivery. The relevance and expected outcome of the proposed study Venous thromboembolism (VTE) is a common and potentially life threatening condition which is still under diagnosed and undertreated.VTE treatment is full of risk as patient requires precise dosing of drugs with careful monitoring.9 Due to these problems in last decade lot of studies were done for developing novel antithrombotic agents. Urokinase is a serine protease (EC 3.4.21.73) enzyme which is also called urokinase-type plasminogen activator (uPA). It is a thromobolytic agent. It was originally isolated from human urine, but it is also found in blood stream and the extracellular matrix. Urokinase directly activates conversion of plasminogen to plasmin which is a primary protein accountable for fibrinolysis.10 Urokianse has a half-life of 10-20 mins due to which it is not available in body for longer time. There is urgent need of a carrier which can carry the urokinase for longer time. Aquasomes is an answer for this need. As it carry the peptide with full retention of therapeutic activity for longer time. So there is a need of developing a drug delivery system for delivery of Urokinase in sustain manner11 It is projected that propose system can add new dimension in delivery of urokianse through its rapid onset of action, maximal efficacy and safety. References Degim IT, Celebi N. Controlled delivery of peptides and proteins. Curr Pharm Des 2007;13:99-117 Erdogan S, Ozer AY, and Bilgili H. In vivo behaviour of vesicular urokinase. Int. J. Pharm.2005 295: 1–6 Juliano RL. Microparticulate drug carriers: liposomes, microspheres and cells. In: Robinson JR, Lee VHL, editors. Controlled drug delivery. 2nd ed. New York: Marcel Dekker, Inc.; 2005. p. 555-80. Rawat M, Singh D, Saraf S, Saraf S. Nanocarriers: promising vehicles for bioactive drugs. Biol Pharm Bull 2006; 29:1790-8. Kossovsky N, Gelman A, Rajguru S, Nguyan R, Sponsler E, Hnatyszyn CK, et al. Control of molecular polymorphism by a structured carbohydrate/ceramic delivery vehicle-aquasomes. J Control Release 1996; 39:383-8. Cherian AK, Rana AC, Jain SK. Self-assembled carbohydrate-stabilized ceramic nanoparticles for the parenteral delivery of insulin. Drug Dev Ind Pharm 2000;26:459-63. Oviedo RI, Lopez SAD, Gasga RJ, Barreda CTQ. Elaboration and structural analysis of aquasomes loaded with indomethecin. Eur J Pharm Sci 2007; 32:223-30. Vyas SP, Goyal AK, Rawat A, Mahor S, Gupta PN, Khatri K.Nanodecoy system: a novel approach to design hepatitis B vaccine for immunopotentiation. Int J Pharm 2006; 309:227-33. Agarwal S, Lee AD, Raju RS, Stephen E. Venous thromboembolism: A problem in the Indian/Asian population? Indian J Urol 2009; 25:11-6. Agarwal Y.K, Vaidya H, Bhatt H, Manna K, Brahmkshatriya P Recent Advances in the Treatment of Thromboembolic Diseases: Venous Thromboembolism Medicinal Research Reviews, 2007 ; 27:891-914, Kaur K,Kush P,Pandey RS,Madan J,Jain UK,Katare OP Stealth lipid coated aquasomes bearing recombinant human interferon-ÃŽ ±-2b offered prolonged release and enhanced cytotoxicity in ovarian cancer cells.2015; 59 :267–276 (b) Objective (s) of the Research Urokinase is an unstable (half-life of 10-20 mins) enzyme. Pharmacist plays and important role in their stabilization, formulation and effective delivery. Over all aim of this study is to develop urokinase immobilized aquasome. Aquasome will protect urokinase from degradation and dehydration. It will also enhance and sustain its thrombolytic activity with reduced side effects. Specific objectives will be 1. To synthesize aquasomes having different compositions. Aquasomes with different sugar coating will be synthesized. Sucrose, Trehalose , Lactose and Pyrodoxial-5-phospahte will be used for sugar coating. Characterization of these nanoparticulte system will done using Transmission electron microscopy, Scanning electron microscopy, Zetasizer and X-ray powder diffractometry (XRPD). Determination of particle morphology and distribution size analysis of nanoparticles will be performed. 2 To immobilize urokinase on aquasomes and coating of PEGylated phospholipids Optimization of aquasome formulations for maximum loading of enzyme will be performed. Enzyme activity will be measured for immobilized enzyme and later they will be coated with PEGylated phospholipids for sustain release. 3. Characterization of these nanoparticulte systems after immobilization will be performed using Transmission electron microscopy, Scanning electron microscopy and Zetasizer 3. In-Vitro evaluation of aquasomal formulations Aquasomal formulations will evaluated for protein (Urokinase) release. (c) Methodology The envisaged work shall be undertaken on the following lines (1) Preformulation studies 1.1. Identification test for proteins IR spectroscopy SDS PAGE 1.2. Identification Test of Formulation Adjuvants (Sugars) Molish Test Moore’s Test Polarimetric determination of sugars 1.3. Preparation of calibration curve of adjuvants (Trehalose and Cellobiose) 1.4. Preparation of calibration curve of Enzyme as a Protein 1.5 Preparation of Calibration curve of Enzyme in PBS (pH 7.4) and Plasma (2) Preparation and Characterization of Hydroxy Apatite 2.1 Optimization of the method for the preparation of Hydroxy Apatite 2.1.1 Characterization of Hydroxy Apatite prepared by self-precipitation Size and Shape e.g TEM and SEM Crystal properties e.g XRD 2.1.2 Preparation and Characterization of Aquasome 2.1.3 Optimization of the poly hydroxyl Oligomers concentration on Hydroxy Apatite 2.1.4 Optimization of drying condition 2.1.5 Optimization of Protein concentration 2.16 Characterization of Optimized Aquasome formulation. Confirmation of poly hydroxyl Oligomers coating by Zeta Potential measurement Determination of loading efficiency of various Aquasome formulations In-vitro release rate studies Assessment of Biodegradability of Different Formulation Retention of Enzyme Activity Reaction Kinetics of Aquasome adsorbed Urokinase Urokinase specific Antibody Detection (3) Stability studies of prepared formulation SDS-PAGE Storage Stability Expected Results/Benefit It is expected that proposed formulation will retain the spatial properties of urokinase i.e. three-dimensional conformation, which is basically achieved by freedom of internal molecular rearrangement for intermolecular interaction and without any bulk movement. Using carbohydrate based aquasomes a high degree of molecular preservation may be achieved by virtue of the significant degree of retained biological activity. The aquasomes also avoid the elimination of drug by reticuloendothelial system therefore sustained and controlled delivery of drug may be achieved. Therefore, it is aim to develop an Aquasome system being streptokinase to protect drug from degradation and dehydration as well as to enhance and sustain its biological activity with reduced side effects. It will help us in getting preliminary results which will be very useful in writing big research project grants to other funding agencies. It is also expected that this research work will allows us to publish quality publications.

Thomas Hart Bentons June Morning. :: essays research papers

  Ã‚  Ã‚  Ã‚  Ã‚  I never go anywhere alone. After a depressive Saturday morning I finally crawled out of bed and went to the Cummer Museum. Art is one thing that I don’t understand. How people can find deeper meanings from paint on a canvas is Japanese to me. When I look at a painting I see exactly what is being shown and nothing more. There is no deeper meaning evident. Being at this museum cranky and solo trying to find a picture I felt connected to was almost impossible. It took me about ten minutes to go through the whole museum. But in one of the last sections I went in there was finally something that my eyes were drawn to. An image that made me want to find the deeper meaning. Thomas Hart Benton’s June Morning.   Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  From across the room I could see the bright yellow, pink and red flowers. Taking some steps forward there was even more to like. The overall appearance is a depiction of everyday life. The setting is outside in a grassy area. The sky looks grey but is turning brighter. There is a house in the country whose owner is in the front milking a cow. There is a dead tree that stands bear in the center. The objects that appear closest are a broken fence and the intensely bright colored flowers. All of the objects seem animated and do not seem realistic. The clouds are grey and sharp. Making the viewer feel that something is wrong. It looks like a storm was just taking place. The wind blew the clouds away and is still blowing the grass to the right.   Ã‚  Ã‚  Ã‚  Ã‚  Somehow I related to this painting at the moment. Looking back in the distance in the sky you see that there was a turbulent time. Saturday was such an awful morning. When backing up you see the bottom of the picture. The lush lively flowers show the bright side happy ending. This was my reminder that there is a calm after the storm just like in the picture.   Ã‚  Ã‚  Ã‚  Ã‚  After coming home I thought it would be a good idea to do some research. What was going on at the time Benton painted, June Morning? This would help to solve the mystery of what some of the symbolism was trying to say. Thomas Hart Benton was a regionalist who used art to depict the experiences of an everyday American.

What is hysteria? Discuss how hysteria was important in the origins of psychoanalysis.

Introduction Throughout the history of psychology, the term Hysteria was used to describe symptoms of illness that were atypical to already established diseases (Feinstein, 2011). Neuropsychiatrists of the 1800-1900s described Hysteria as an illness where dissociation occurs for reasons that are not obvious. The symptoms shown in a hysterical patient are those such as anaesthesia, amnesia, abulia, motor control disorders and changes in personality (Haule, 1986). These symptoms are known today as a type of psychoneurosis which causes emotional excitability, provoking emotions such as fear or panic. Disturbance of the sensory, motor and cognitive functions of humans are also a result of this particular neurosis (Patel, 2012). It has been argued by critics of the DSM that the condition, Hysteria, lacks validity and that the only reason why it lasted as a category of disease throughout history is due to tradition (Feinstein, 2011). Thus, in 1994, the DSM-IV removed ‘hysteria’ as an estab lished disease and divided the symptoms of the disease into two sections now known as Somatoform Disorder and Dissociative Disorder. The issues under these two umbrella terms covered the symptoms that were accepted by the original term ‘hysteria’ (Feinstein, 2011). The DSM-IV stated that the diagnoses for the conditions which lie under the umbrella terms Somatoform Disorder and Dissociative Disorder are particularly relevant to the formerly known diagnostic categories of hysteria. These conditions are Somatisation Disorder, Conversion Disorder and Dissociative Amnesia (Feinstein, 2011). Conversion Disorder was the most closely associated to the disorders that were treated by Charcot and Freud in the 1900s, and refers to symptoms that mimic neurological disorders such as motor and sensory deficits, pseudo seizures and mixed presentations. These symptoms should not relate to any organic source of illness, nor be associated with substance use/abuse or the patients particip ation in culturally endorsed behaviours such as trances during religious ceremonies in order for them to be and have been diagnosed as hysteria (Feinstein, 2011). The aim of the present essay is to outline what hysteria was, and how it related to psychoanalysis. So, although the symptoms of hysteria are now represented through separate categories of mental disorders in the Diagnostic and Statistical Manual in the present day, for the purpose of this essay, the term hysteria will be used to encapsulate all of the symptoms, and in order to embody the historical and contextual term whilst discussing the relevance of the condition to the origins of psychoanalysis. The literature suggests that the causes of hysteria are linked to past traumas, conflict, undue stress such as bereavement and a history of abuse (Patel, 2012). It has also been theorised that repression of sexual or aggressive behaviours could trigger hysteria. This concept was best conveyed through Freud’s work on pat ient Anna O, where psychoanalysis had begun to take form. Freud had treated Anna O for symptoms of Hysteria by joining Breuer’s talk therapy and Charcot’s view of hysteria (Webster, 2004). Anna O’s symptoms represented the typical manifestation of hysteria. Physical symptoms consisted of a cough, paralysis on the right side of the body, contractures, and disturbances in vision, hearing and language. Psychological symptoms consisted of lapses in consciousness and frequent hallucinations. These symptoms are similar to the modern day indicators of Conversion Disorder. Doctors found no organic cause for Anna O’s symptoms, so as a result of this, she was diagnosed with hysteria. Through the work on Anna O, an outline for psychoanalysis had begun to emerge (Webster, 2004). Freud continued to use the same therapeutic techniques on other patients who displayed the symptoms of hysteria, consequently bringing psychoanalysis into full bloom (Webster, 2004). The proc ess of exploring concepts such as the unconscious, repression and intrapsychic conflict in hysterical patients aided the development of psychoanalysis. Hypnosis, directive and abreactive techniques, and an early form of free association were used with these patients. Through these experiments Freud was able to strengthen the foundation of his psychoanalytical theory by adding these techniques to his practice of psychoanalysis (Krohn, 1978). Freudian psychoanalytic theory, and its associated practice, psychoanalysis, placed emphasis on the theory of the unconscious mind. Freud had proposed that the mind was composed of three components: the id, ego and superego. These components were suggested to play a significant role in the development of hysteria and are best explained through their association to the psychosexual stages of development (Yarom, 2005). The psychosexual stages of development encompass the Oral, Anal, Phallic, Latent and Genital phases. The theory holds the standpoin t that the ego develops during the Oral phase, and the superego develops during the Phallic phase. The subject of hysteria has widely been studied in ego psychology and its understanding was enhanced in the more recent studies throughout the literature, as a personality disorder related to conflicts within the ego (Yarom, 2005). Psychoanalytic theory had proposed that the ego and the superego were developed by the psyche in order to put into effect some control over the libido during psychosexual development and throughout adult life, so that need for gratification is directed into socially acceptable ways. Freud had stated that need for gratification is associated with the different parts of the body during each stage of psychosexual development, thus the conflict between the id, ego and the superego is associated with whichever psychosexual stage the individual is at (McLeod, 2008). The conflict within the psyche at the Phallic stage is what has been theorised to bring about the O edipus and Electra Complexes in individuals (McLeod, 2008). The suggestion made by Freud was that hysteria was associated with rejected sexuality. Freud put forward strong references to the female sexuality. This connection was made through the theory of the Electra complex in which females are said to have unconscious incestuous wishes and envy the penis of their male caregivers. For this reason, hysteria was a disease strongly related to women (Yarom, 2005) On the other hand, neo-Freudian approaches, such as that of Horney’s (1967) suggested that penis envy should be considered as a secondary as opposed to primary phenomenon, in the sense that women’s sexual identities are more focused on aspirations to bear children rather than achieve orgasm. However, it may be suggested that this still provides a sexist standpoint against women as it portrays women as only being interested in bearing children. Nonetheless, sexism was slowly overcome as history progressed and this was evident through the fact that hysteria gradually became a disorder that was associated with males as well as females (Yarom, 2005). Yet contradictory literature shows studies during the 1970s which still insisted that hysteria was more prevalent among women than men, with a high comorbidity evident between sociopathy and hysteria, especially in women (Cloninger & Guze, 1971). These findings are supported by Lerner (1974) who stated that hysteria is a disease frequently applied to women and less frequently, if never, to men. However, despite these studies showing evidence in the literature that hysteria is a female only disease, it may be suggested that the chauvinistic and patriarchal nature of society throughout history may have influenced the findings that although males may exhibit hysterical behaviours, it does not necessarily mean that they have the condition hysteria. It may be the case that male researchers did not want to associate this ‘weakness in characterâ€⠄¢ to the male population, therefore put it forth as a female only illness, maintaining the ‘strong’ image of men. Secondly, since the majority of the researchers in this area of interest were males, it may also be suggested that they lacked empathy and understanding of the emotions and behaviours that females were exhibiting, thus interpreted these as more hysterical than those which the males were exhibiting. Conversely, the paper by Lerner (1974) does indicate that hysterical symptoms such as conversion reactions and dissociative phenomena were been observed in men, but that these patients did not display the cognitive and personality characteristics of the hysterical individual, therefore they did not have hysteria. Yet, in any case, when social and contextual factors are taken into consideration, it brings one’s attention to the fact that the doctors and researchers involved in studies of Hysteria were mainly male, reinforcing the notion that the literature was also dominated by observations influenced by patriarchal males. To lend additional support to this view, it was advocated that the explanation of the prevalence of Hysteria among women on the part of psychoanalysts was focused on preoedipal and oedipal developmental tasks that must be mastered by males and females, yet the libidinal development of the two sexes only offers a partial explanation of the alleged sex differences in Hysteria, therefore it is more rational to hold the belief that social and cultural factors play a major role in the issue (Lerner, 1974). With reference to conflict within the psyche during each psychosexual stage, the purpose of psychoanalysis was to aid the patient in bringing forward to consciousness the repressed thoughts and emotions that were associated with these phases. Resolving these conflicts would strengthen the ego (Zimberoff & Hartman, 2000).. In accord, the likelihood of developing hysteria would lessen. This is supported by the notion tha t tension during each phase relies on the way in which the ego deals with anxiety, and that hysteria is a result of manifested repression of an incompatible idea on the ego’s part (Vaillant, 1992). Therefore, the evidence based on the relationship between the id, ego and superego in psychosexual stages and the development of hysteria, played a cruicial role as a catalyst in bringing the theory of psychoanalysis into practice. This is evident through the demonstration of how resolving psychosexual conflicts strengthens the ego, therefore avoiding the development of hysteria. Although the role of Hysteria in the development of psychoanalysis is clear, it must be noted that the patriarchal approach taken by Freud and other researchers during the studies of Hysteria had also reflected on the theory and practice of psychoanalysis (Bernheimer & Kahane, 1985). Freud’s writings were based mainly on male development (McLeod, 2008). This could imply one of two things: Either tha t he held the belief that female development mirrored male development, or that it was inferior to male development. Hence, it is appropriate for one to question the theory that if hysteria was a female only disease, was it a mirror of male hysteriaThis could in turn imply that males were also prone to developing hysteria, therefore weakening the literature throughout history that hysteria was limited to females. On the other hand, it may also be suggested that if only the ‘hysterical symptoms’ that were limited to men, were mirrored by women and were manifested in women as full blown hysteria, that hysteria was in fact a disease in full bloom in males as well as females. If women mirroring the behaviour of men was the case, this would suggest and further reinforce the idea that psychoanalysis the product of a patriarchal foundation, as hysteria was the catalyst which had patriarchal influences attached to it. As a consequence, one is left in a position to question whet her studies on hysteria had influenced psychoanalysis, or whether psychoanalysis had influenced the findings and history of hysteria, as they both appear to be partners in crime when the issue of sexism has been mentioned throughout the literature. In summary, hysteria is a set of symptoms known in the modern day as three different categories of mental disorder, classified by the DSM-IV as: Somatisation Disorder, Conversion Disorder and Dissociative Amnesia. These three categories include the indicators of hysteria such as anaesthesia, amnesia, abulia, motor control disorders and changes in personality. Modern psychology suggests that hysteria is brought on through past traumas, conflict, undue stress such as bereavement and a history of abuse. However, throughout the history of psychology, it was believed that hysteria was the ego’s reaction to suppressed sexual or aggressive behaviours. Freud, Charcot and Breuer played significant roles in the establishment of the term hyst eria, and Anna O had been the first patient to be treated for the symptoms of hysteria. Through the practice of talking therapy and free association, Freud began to establish the theory of psychoanalysis as he worked with Anna O. Theories of the unconscious mind and its components, the id, ego and superego began to emerge as Freud established their roles in the development of the human psyche. Later, hypnosis, directive and abreactive techniques, were used with Freud’s patients. It was through the founding of the psychosexual stages of development that psychoanalysis began to blossom in full bloom. Many doctors in the 1800-1900s had associated hysteria with females, considering it to be a women’s only disease and suggesting that men merely showed symptoms of the disease – not a complete case (Lerner, 1974). For this reason, Freud had suggested that the conflict of the psyche during the Phallic stage, especially for females, whom struggled with penis envy, was wh at manifested as Hysteria at a later stage in life (Yarom, 2005). However, subsequent and more recent speculation highlighted the fact that these findings were discovered during a highly patriarchal time in history, where the medical field was widely dominated by men. Thus, it became evident that hysteria was, and still is a mental disorder found to be equally as prevalent in both men and women (Tucker, 2009). In conclusion, with respect to the essay question at hand, it was considered that hysteria was a significant foundation and catalyst for the development of psychoanalysis. However, due to the fact that hysteria itself was a flawed phenomenon in the way it was reflected throughout the literature at the time, psychoanalysis also became a skewed theory, based on patriarchal and chauvinistic theories. Nonetheless, this does not change the fact that Hysteria, and Anna O played a major role in the founding of psychoanalysis. Moreover, it should be considered that Hysteria is now an outdated term. The symptoms have been revised and the categories for the symptoms have been divided by the DSM, reflecting the progression that psychological literature has made since the time of Freud and psychoanalysis. References Bernheimer, C. and Kahane, C. (1985). In Dora’s case. 1st ed. New York: Columbia University Press. Clonninger, C. and Guze, S. (1970). Psychiatric Illness and Female Criminality: The Role of Sociopathy and Hysteria in the Antisocial Woman. American Journal of Psychiatry. 127(3), pp.303-311. Feinstein, A. (2011). Conversion disorder: advances in our understanding. Canadian Medical Association Journal. 183(8). 915-920. Haule J.R. (1986). Pierre Janet and dissociation: the first transference theory and its origins in Hypnosis. Am J Clin Hypnosis. 29: 86-94 Horney, K. (1967). Feminine psychology. 1st ed. New York: W.W. Norton. Krohn, A. (1978). Hysteria, the elusive neurosis. 1st ed. New York: International Universities Press. McLeod, S. (2014). Psychosexual Stages | Simply Psychology. [online] Simplypsychology.org. Available at: http://www.simplypsychology.org/psychosexual.html [Accessed 24 Apr. 2014]. Patel, M. and Patel, M. (2012). An Introduction to Hysteria: Causes Symptoms and Treatment. [online] mDhil. Available at: http://www.mdhil.com/an-introduction-to-hysteria/ [Accessed 24 Apr. 2014]. Psychologistworld.com, (2014). Sigmund Freud – Psychology Issues – Psychologist World. [online] Available at: http://www.psychologistworld.com/psychologists/freud_1.php [Accessed 24 Apr. 2014]. Webster, R. (2014). Anna O and Hysteria: Charcot and the origins of psychoanalysis. [online] Available at: http://www.richardwebster.net/print/xfreudandcharcot.htm [Accessed 24 Apr. 2014]. Vaillant, G.E. (1992). Ego Mechanisms of Defense: A Guide for Clinicians and Researchers. Washington, DC: American Psychiatric Press. Yarom, N. (2005). Matrix of hysteria. 1st ed. London: Routledge. Zimberoff, D. and Hartman, D. (2000). Ego Strengthening and Ego Surrender. Journal of Heart-Centered Therapies, 3(2), pp.3-66.

Pictures and Profiles of Prehistoric Primates